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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T62002 | Topoisomerase I inhibitor 7 | ||
Topoisomerase I inhibitor 7 (Compound 8) is a potent inhibitor of Topoisomerase I. Topoisomerase I inhibitor 7 significantly inhibits tumor growth (up to 79%) and increases the lifespan (153%) of mice bearing P388 lympho... | |||
TQ0134 | Podocarpusflavone A | Topoisomerase | |
Podocarpusflavone A is a DNA topoisomerase I inhibitor. It has moderated anti-proliferative activity induce cell apoptosis in MCF-7. | |||
T61990 | Topoisomerase I/II inhibitor 3 | ||
Topoisomerase I/II inhibitor 3 (compound 7) is a potent dual inhibitor of topoisomerase I (Topo I) and II (Topo II) . By inhibiting PI3K /Akt/mTOR signaling pathway, Topoisomerase I/II inhibitor 3 can inhibit cell prolif... | |||
T61501 | Topoisomerase I inhibitor 5 | ||
Topoisomerase I inhibitor 5 is an efficient inhibitor of topoisomerase I, with an IC50 value. It effectively disrupts DNA and inhibits the activity of topoisomerase I. Moreover, it can induce apoptosis in MCF-7 cells and... | |||
T61717 | Topoisomerase I inhibitor 4 | ||
Topoisomerase I inhibitor 4 (compound 7a) is a potent inhibitor of topoisomerase I activity. It effectively inhibits the proliferation of various cancer cell lines including HepG2, A549, MCF-7, and HeLa, with IC50 values... | |||
T77873 | NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride | Topoisomerase | |
Compound I, NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride, is a topoisomerase I inhibitor that demonstrates effective antibody-drug conjugate (ADC) activity both in vivo and in vitro, with delivery to cells facilit... | |||
T74750 | NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT | ||
Compound I, NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT, is a topoisomerase I inhibitor with the capability for targeted delivery to cells via conjugated antibodies. It exhibits effective ADC activity both in vivo and in vitro... | |||
T74751 | Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT | ||
Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT (Formula V) is a conjugate comprising a potent topoisomerase I inhibitor linked to an antibody agent conjugate (ADC) [1] through a specialized linker. | |||
T36695 | TAS-103 | ||
TAS-103 is a dual inhibitor of DNA topoisomerase I/II, used for cancer research. TAS-103 is a dual inhibitor of DNA topoisomerase I/II. TAS-103 (0.1-10 μM) is active on CCRF-CEM cells, with an IC50 value of 5 nM. TAS-103... |